Detox Supplement Scientific Research

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On this page, you’ll find cited resources for the claims made for the dietary detox supplements listed on this page: 30 Best Detox Drinks for Fast Weight Loss (Updated for 2022).

1. TeaBurn Scientific References

introducing teaburn dietary supplement

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1. Adeva-Andany, María M et al. “Significance of l-carnitine for human health.” IUBMB life vol. 69,8 (2017): 578-594. doi:10.1002/iub.1646

2. Askarpour, Moein et al. “Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials.” Pharmacological research vol. 151 (2020): 104554. doi:10.1016/j.phrs.2019.104554

3. Baba, Yoshitake et al. “Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-controlled Study.” Journal of medicinal food vol. 24,4 (2021): 333-341. doi:10.1089/jmf.2020.4803

4. Broadhurst, C Leigh, and Philip Domenico. “Clinical studies on chromium picolinate supplementation in diabetes mellitus–a review.” Diabetes technology & therapeutics vol. 8,6 (2006): 677-87. doi:10.1089/dia.2006.8.677

5. Center, Sharon A et al. “Influence of dietary supplementation with (L)-carnitine on metabolic rate, fatty acid oxidation, body condition, and weight loss in overweight cats.” American Journal of veterinary research vol. 73,7 (2012): 1002-15. doi:10.2460/ajvr.73.7.1002

6. Cha, Y S et al. “Effects of carnitine coingested caffeine on carnitine metabolism and endurance capacity in athletes.” Journal of nutritional science and vitaminology vol. 47,6 (2001): 378-84. doi:10.3177/jnsv.47.378

7. Cho, Ae-Sim et al. “Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced obese mice.” Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association vol. 48,3 (2010): 937-43. doi:10.1016/j.fct.2010.01.003

8. Di Pierro, Francisco et al. “Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial.” Alternative medicine review: a journal of clinical therapeutic vol. 14,2 (2009): 154-60.

9. Dulloo, A G et al. “Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans.” The American Journal of Clinical nutrition vol. 70,6 (1999): 1040-5. doi:10.1093/ajcn/70.6.1040

10. Dulloo, A G et al. “Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity.” International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity vol. 24,2 (2000): 252-8. doi:10.1038/sj.ijo.0801101

11. Gilardini, Luisa et al. “Effects of Greenselect Phytosome® on weight maintenance after weight loss in obese women: a randomized placebo-controlled study.” BMC complementary and alternative medicine vol. 16 233. 22 Jul. 2016, doi:10.1186/s12906-016-1214-X

12. Gosselin, Chantal, and François Haman. “Effects of green tea extracts on non-shivering thermogenesis during mild cold exposure in young men.” The British journal of nutrition vol. 110,2 (2013): 282-8. doi:10.1017/S0007114512005089

13. Haskell, Crystal Fet al. “The effects of L-theanine, caffeine and their combination on cognition and mood.” Biological psychology vol. 77,2 (2008): 113-22. doi:10.1016/j.biopsycho.2007.09.008

14. Katada, Shun et al. “Effects of Chlorogenic Acid-Enriched and Hydroxyhydroquinone-Reduced Coffee on Postprandial Fat Oxidation and Antioxidative Capacity in Healthy Men: A Randomized, Double-Blind, Placebo-controlled, Crossover Trial.” Nutrients vol. 10,4 525. 23 Apr. 2018, doi:10.3390/nu 10040525

15. Koozehchian, Majid S et al. “Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males.” Journal of exercise nutrition & biochemistry vol. 22,4 (2018): 7-19. doi:10.20463/jenb. 2018.0026

16. Ludwig, Iziar A et al. “Coffee: biochemistry and potential impact on health.” Food & function vol. 5,8 (2014): 1695-717. doi:10.1039/c4f000042k

17. Madsen, Karen Lindhardt et al. “L-Carnitine Improves Skeletal Muscle Fat Oxidation in Primary Carnitine Deficiency.” The Journal of clinical endocrinology and metabolism vol. 103,12 (2018): 4580-4588. doi:10.1210/jc.2018-00953

18. Meng 5, Cao J, Feng Q, Peng), HyY. Roles of chlorogenic Acid on regulating glucose and lipids metabolism: a review. Evid Based Complement Alternat Med. 2013;2013:801457. doi:10.1155/2013/801457

19. Naveed M, Hejazi V. Abbas M, Kamboh AA, Khan GJ, Shumzaid M, Ahmad F. Babazadeh D, Fang Fang X, Modarresi-Ghazani F, Wen Hua L, Xiao Hui Z. Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomed Pharmacother. 2018 Jan;97:67-74. doi: 10.1016/j.biopha.2017.10.064. Epub 2017 Nov 6.

20. Nieber, Karen. “The Impact of Coffee on Health.” Planta medica vol. 83,16 (2017): 1256-1263. doi:10.1055/5-0043-115007

21. Nussbaumerova, Barbora et al. “Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and impaired Glucose Tolerance.” Biological trace element research vol. 183,2 (2018): 192-199. doi:10.1007/s12011-017-1128-6

22. Paiva, Ana N et al. “Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study.” Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS) vol. 32 (2015): 66-72. doi:10.1016/j.jtemb.2015.05.006

23. Park, Sang-Ki et al. “A combination of green tea extract and I-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study.” Journal of medicinal food vol. 14,4 (2011): 334-43. doi:10.1089/jmf.2009.1374

24. Patti, Angelo Maria et al. “Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients with Metabolic Syndrome.” Angiology vol. 66,9 (2015): 856-61. doi:10.1177/0003319714568792

25. Racek, Jaroslav et al. “Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus.” Biological trace element research vol. 109,3 (2006):215-30. doi:10.1385/BTER:109:3:215

26. Santana-Gálvez], Cisneros-Zevallos L. Jacobo-Velázquez DA. Chlorogenic Acid: Recent Advances on its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome. Molecules. 2017 Feb 26;22(3):358. doi: 10.3390/molecules22030358. PMID: 28245635; PMCID: PMC6155416.

27. Sharma, Shilpi et al. “Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type 2 diabetes.” Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS) vol. 25,3 (2011): 149-53. doi:10.1016/j.jtemb.2011.03.003

28. Shixian, Q et al. “Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase.” Journal of medicinal food vol. 9,4 (2006): 451-8. doi:10.1089/jmf.2006.9.451

29. Soga, Satoko et al. “Stimulation of postprandial fat utilization in healthy humans by daily consumption of chlorogenic acids.” Bioscience, biotechnology, and biochemistry vol. 77,8 (2013): 1633-6. doi:10.1271/bbb.130147

30. Suksomboon, N et al. “Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes.” Journal of clinical pharmacy and therapeutics vol. 39,3 (2014): 292-306. doi:10.1111/jcpt.12147

31. Tajik, Narges et al. “The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature.” European Journal of nutrition vol. 56,7 (2017): 2215-2244. doi:10.1007/s00394-017-1379-1

32. Talenezhad, Nasir et al. “Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis.” Clinical nutrition ESPEN vol. 37 (2020): 9-23. doi:10.1016/j.clnesp.2020.03.008

33. Thielecke, Fet al. “Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study.” European journal of Clinical nutrition vol. 64,7 (2010): 704-13. doi:10.1038/ejcn.2010.47

34. Thom, E. “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.” The Journal of international medical research vol. 35,6 (2007): 900-8. doi:10.1177/147323000703500620

35. Van Schaik, Lachlan et al. “Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review.” Frontiers in neuroscience vol. 15 621356.4 Feb. 2021, doi:10.3389/fnins.2021.621356

36. Velickovic, Ksenija et al. “Caffeine exposure induces browning features in adipose tissue in vitro and in vivo.” Scientific reports vol. 9,1 9104. 24 Jun. 2019, doi:10.1038/541598-019-45540-1

37. Wall, Benjamin T et al. “Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans.” The Journal of physiology vol. 589,Pt 4 (2011): 963-73. doi:10.1113/jphysiol.2010.201343

38. Watanabe, Takuya et al. “Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial.” Nutrients vol. 11,7 1617. 16 Jul. 2019. doi:10.3390/nu11071617

39. Westerterp-Plantenga, Margriet S et al. “Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation.” Obesity research vol. 13,7 (2005): 1195-204. doi:10.1038/oby.2005.142

40. Williams J, Mckune AJ, Georgousopoulou EN, Kellett J, D’Cunha NM, Sergi D, Mellor D, Naumovski N. The Effect of L-Theanine Incorporated in a Functional Food Product (Mango Sorbet) on Physiological Responses in Healthy Males: A Pilot Randomised Controlled Trial. Foods. 2020 Mar 23:9(3):371. doi: 10.3390/foods9030371. PMID: 32210015; PMCID: PMC7142516.

41. Williams, Jackson L et al. “The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to manage Stress and Anxiety Levels: a Systematic Review.” Plant foods for human nutrition (Dordrecht, Netherlands) vol. 75,1 (2020): 12-23. doi:10.1007/s11130-019-00771-5

42. Yoneshiro, Takeshi et al. “Tea catechin and caffeine activate brown adipose tissue and increase cold-induced thermogenic capacity in humans.” The American Journal of clinical nutrition vol. 105,4 (2017): 873-881. doi:10.3945/ajcn. 116.144972

43. Yoto, Ai et al. “Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses.” Journal of physiological anthropology vol. 31,1 28. 29 Oct. 2012, doi:10.1186/1880-6805-31-28

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2. Synogut Scientific References

synogut dietary supplement

www.Synogut.com

“High-fiber diet keeps gut microbes from eating the colon’s lining, protects against infection, animal study shows”, article available at: https://www.uofmhealth.org/news/archive/201611/high-fiber-diet-keeps-gut-microbes-eating-colon%E2%80%99s-lining

“Bentonite clay: 11 benefits and uses”, article available at: https://www.medicalnewstoday.com/articles/325241

“You’re full of crap. Literally”, article available at: https://www.mcgill.ca/oss/article/health/youre-full-crap-literally

“A 24-Year-Old Man’s ‘Megacolon’ Burst After He Was Constipated for Nine Days”, article available at: https://www.menshealth.com/health/a22839233/megacolon-burst-constipation/

“Symptomatic efficacy of beidellitic montmorillonite in irritable bowel syndrome: a randomized, controlled trial”, study available at: https://pubmed.ncbi.nlm.nih.gov/15709995/

“Millions of Americans have a parasite and don’t realise it”, article available at: https://www.vice.com/en/article/a3m88j/millions-of-americans-have-a-parasite-and-dont-realize-it

“Preventive obesity agent montmorillonite adsorbs dietary lipids and enhances lipid excretion from the digestive tract”, study available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759552/

“9 Ways Lactobacillus Acidophilus Can Benefit Your Health”, article available at:
https://www.healthline.com/nutrition/lactobacillus-acidophilus

“A Randomized Double-blind Controlled Trial of Lactobacillus acidophilus Plus Bifidobacterium bifidum versus Placebo in Patients with Hypercholesterolemia”, study available at: https://pubmed.ncbi.nlm.nih.gov/25954637/

“Walnuts may promote health by changing the gut bacteria”, article available at:
https://www.sciencedaily.com/releases/2017/07/170728100832.htm

“Top 5 benefits of drinking Aloe”, article available at: https://www.detoxwater.com/blogs/news/top-5-health-benefits-of-drinking-aloe

“Effect of Aloe vera juice on growth and activities of Lactobacilli in-vitro”, study available at:
https://pubmed.ncbi.nlm.nih.gov/23762993/

“Aloe probiotics are very acid tolerant”, article available at:
https://www.nutritionaloutlook.com/view/probiotics-aloe-are-very-acid-tolerant

“Aloe vera and probiotics: A new alternative to symbiotic functional foods”, study available at:
https://orbit.dtu.dk/en/publications/aloe-vera-and-probiotics-a-new-alternative-to-symbiotic-functiona

“The 19 Best Prebiotic Foods You Should Eat”, article available at:
https://www.healthline.com/nutrition/19-best-prebiotic-foods

“This Pantry Staple Could Do Wonders for Your Microbiome, Study Says”, article available at: https://www.cookinglight.com/news/flaxseed-gut-health-benefits

“The top health benefits of prunes”, article available at: https://www.healthline.com/health/food-nutrition/top-benefits-of-prunes-prune-juice

“9 health benefits of eating oats”, article available at:
https://www.healthline.com/nutrition/9-benefits-oats-oatmeal

“10 promising benefits of apple pectin”, article available at: https://www.healthline.com/nutrition/apple-pectin

Synogut Nutrition Label

syg label

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3. Biofit Scientific References

biofit bottles next to website and ebook

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Kim, Jooheen,, Jae Moon Yun, Mi Kyung Kim, Oran Kwon, and Belong Cho (2018). Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial Journal of Medicinal FoodVol. 21, No. 5. Retrieved from: https://www.liebertpub.com/doi/10.1089/jmf.2017.3937

Nozawa, Mai (2015). Morinaga Milk Industry: Probiotic Supplementation Causes Fat Loss in Overweight Adults. Business Wire, Berkshire Hathaway Company. Retrieved from: https://www.businesswire.com/news/home/20150624005038/en/Morinaga-Milk-Industry-Probiotic-Supplementation-Fat-Loss

Carlota, Maria, Dao Amandine, Everard Karine, Clément Patrice, D.Can (2016). Losing weight for a better health: Role for the gut microbiota. Clinical Nutrition Experimental Volume 6, April 2016, Pages 39-58. Retrieved from: https://www.sciencedirect.com/science/article/pii/S2352939315000202

Sanchez, Maria (2013). Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women. British Journal of Nutrition, 2014 Apr 28;111(8):1507-19. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/24299712/

Tran, Thu Hoa,Le Hong Duc,Rachele Isticato, Loredana Baccigalupi,Ezio Ricca, Pham Hung Van,and Simon M. Cutting. (2001) Fate and Dissemination of Bacillus subtilis Spores in a Murine Model. Applied Environmental Ecology, 2001 Sep; 67(9): 3819–3823. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC93096/

Bobae Kim,Jeonghyeon Kwon,Min-Seok Kim,Haryung Park,Yosep Ji,Wilhelm Holzapfel,Chang-Kee Hyun (2018). Protective effects of Bacillus probiotics against high-fat diet-induced metabolic disorders in mice. PLOS ONE. Retrieved from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210120

J. Minami et al. (2015). Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomized controlled trial. Journal of Nutritional Science, vol.4, e17;1-7, 2015. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463018

Akshat, Rathi. (2016) Can’t lose weight? You might be able to blame it on your parents—and their gut bacteria. Quartz. Retrieved from: https://qz.com/791056/twins-study-links-gut-bacteria-to-body-fat/

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4. The Smoothie Diet Scientific Research

The Smoothie Diet was designed by a board-certified health coach. Learn more about the science behind the Smoothie Diet on their website.

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5. Okinawa Flat Belly Tonic Scientific Research

Okinawa Flat Belly Tonic Website

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(1) Effects of Green Tea and Its Epigallocatechin (EGCG) Content on Body Weight and Fat Mass in Humans: A Systematic Review [Article in Spanish]. Lucía Cristina Vázquez Cisneros 1 , Patricia López-Uriarte, Antonio López-Espinoza, Mónica Navarro Meza, Ana Cristina Espinoza-Gallardo, Martha Beatriz Guzmán Aburto. Nutr Hosp. 2017
https://pubmed.ncbi.nlm.nih.gov/28627214/

(2) New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate. Kim HS, Quon MJ, Kim JA. Redox Biol. 2014https://pubmed.ncbi.nlm.nih.gov/24494192/

(3) Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases. Pervin M, Unno K, Ohishi T, Tanabe H, Miyoshi N, Nakamura Y. Molecules. 2018 https://pubmed.ncbi.nlm.nih.gov/29843466/

(4) Piperine, a Component of Black Pepper, Inhibits Adipogenesis by Antagonizing PPARγ Activity in 3T3-L1 Cells. Ui-Hyun Park, Hong-Suk Jeong, Eun-Young Jo, Taesun Park, Seung Kew Yoon, Eun-Joo Kim, Ji-Cheon Jeong, and Soo-Jong Um. Journal of Agricultural and Food Chemistry. 2012 https://pubmed.ncbi.nlm.nih.gov/22463744/

(5) Pathology, Inflammation. Stone WL, Basit H, Burns B. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2020. https://www.ncbi.nlm.nih.gov/books/NBK534820/

(6) Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5’D activity in adult male mice. Panda S, Kar A. Horm Metab Res. 2003 https://pubmed.ncbi.nlm.nih.gov/14517767/

(7) Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Chambers ES, Viardot A, Psichas A, et al. Gut. 2015 https://pubmed.ncbi.nlm.nih.gov/25500202/

(8) A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Guess ND, Dornhorst A, Oliver N, Bell JD, Thomas EL, Frost GS. Nutr Metab (Lond). 2015 https://pubmed.ncbi.nlm.nih.gov/26500686/

(9) Dietary Alteration of the Gut Microbiome and Its Impact on Weight and Fat Mass: A Systematic Review and Meta-Analysis. John GK, Wang L, Nanavati J, Twose C, Singh R, Mullin G. Genes (Basel). 2018 https://pubmed.ncbi.nlm.nih.gov/29547587/

(10) Momordica charantia Administration Improves Insulin Secretion in Type 2 Diabetes Mellitus. Marisol Cortez-Navarrete, Esperanza Martínez-Abundis, Karina G. Pérez-Rubio, Manuel González-Ortiz, and Miriam Méndez-del Villar. Journal of Medicinal Food. Jul 2018
https://pubmed.ncbi.nlm.nih.gov/29431598/

(11) Wild bitter gourd improves metabolic syndrome: a preliminary dietary supplementation trial. Tsai CH, Chen EC, Tsay HS, Huang CJ. Nutr J. 2012
https://pubmed.ncbi.nlm.nih.gov/22243626/

(12) Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans. Chang HC, Peng CH, Yeh DM, Kao ES, Wang CJ. Food Funct. 2014
https://pubmed.ncbi.nlm.nih.gov/24549255/

(13) Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). Gurrola-Díaz CM, García-López PM, Sánchez-Enríquez S, Troyo-Sanromán R, Andrade-González I, Gómez-Leyva JF. Phytomedicine. 2010 https://pubmed.ncbi.nlm.nih.gov/19962289/

(14) Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers. Mertens-Talcott SU, Rios J, Jilma-Stohlawetz P, et al. J Agric Food Chem. 2008
https://pubmed.ncbi.nlm.nih.gov/18693743/

(15) Diet supplementation with acai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats. de Souza MO, Silva M, Silva ME, Oliveira Rde P, Pedrosa ML. Nutrition. 2010 https://pubmed.ncbi.nlm.nih.gov/20022468/

(16) Euterpe oleracea (açai) modifies sterol metabolism and attenuates experimentally-induced atherosclerosis. Feio CA, Izar MC, Ihara SS, et al. J Atheroscler Thromb. 2012
https://pubmed.ncbi.nlm.nih.gov/22139433/

(17) Rutin ameliorates obesity through brown fat activation. Yuan X, Wei G, You Y, et al. FASEB J. 2017 https://pubmed.ncbi.nlm.nih.gov/28049156/

(18) Improvement of blood glucose levels and obesity in mice given aronia juice by inhibition of dipeptidyl peptidase IV and α-glucosidase. Takuya Yamanea, Miyuki Kozukab, Daisuke Kondaa,Yoshihisa Nakanoc, Takenori Nakagakid, Iwao Ohkuboe, HiroyoshiArigaa. The Journal of Nutritional Biochemistry. 2016 https://pubmed.ncbi.nlm.nih.gov/27133429/

(19) The involvement of a polyphenol-rich extract of black chokeberry in oxidative stress on experimental arterial hypertension. Ciocoiu M, Badescu L, Miron A, Badescu M. Evid Based Complement Alternat Med. 2013 https://pubmed.ncbi.nlm.nih.gov/23533529/

Okinawa Flat Belly Tonic Website